We use network science and data analysis to decipher collective phenomena at biological and social scales
We are interested in discovering novel bioactive microbial metabolites. Microbial metabolites play important roles in medicine and they are a key source of antibiotics, anticancer agents or immunosuppressants. We develop sequencing, bioinformatics and synthetic biology methods to rapidly detect and characterize novel genes responsible for the biosynthesis of cryptic microbial metabolites. We also work on involving the general public in helping to source new medicines through citizen science projects.
Our research revolves around bacteria and their viruses, phages.
Facing the abundance and diversity of their viruses, bacteria and archaea have developed multiple lines of defense that can be referred to as « prokaryotic immune systems« . Our research focuses on these anti-phage immune systems. We are trying to understand evolutionary patterns and molecular mechanisms of these systems but also how to use them for medical applications. We work at several scales: from computational genomic analysis on thousands of prokaryotic genomes to experimental molecular genetics and diverse microbiology tools.
We develop research projects that place the body in motion at the heart of learning by leveraging digital technologies.
By combining Science & Design, we explore movement and gesture for learning in Education, Sport, Health & Art. In front of a digitized environment composed of screens (mouse & keyboard), which freeze the body, we are working at reversing this current paradigm. Through scientific research and in collaboration with field-actors, we then design tangible interfaces with embedded sensors.
The Motion Lab is an interdisciplinary community of designers and scientists who share a common vision of the significant values of practice-based research.
We use the principles of commons-based peer-production to create knowledge from bottom-up citizen science projects.
The Lindner team’s main efforts rely on years of investment in building an intellectual and experimental framework based on interdisciplinary approaches, harnessing physics and computer science and on welcoming young researchers to address key questions in Life Sciences with Systems and Synthetic Biology approaches, mainly focusing on Escherichia coli as the simplest (yet still not fully understood) model organism. Focal projects include study of phenotypic variability, ageing, evolution of cooperation, probing RNA structure in vivo and RNA scaffolding.
We also develop open and citizen science projects extended from antimicrobial drug discovery and democratizing DNA detection to supporting Open Collaborative Efforts for Autism spectrum Network (OCEAN).
The team is at the core of building the CRI Collaboratory research effort and contributes to developing the CRI undergraduate and graduate programs as well as outreach learning through research programs across the globe. For the past 13 years, the team mentored the Paris Bettencourt iGEM team.
We work at the frontier of political sciences, sociology, and cognitive sciences on the one hand, and mathematics and computer sciences on the other. We rely on massive web, social media, and survey data, aided by High Performance Computer Clusters. We bring these models and tools to the study of epistemically-demanding phenomena occurring in large algorithmically-mediated social and political systems. Several of the phenomena that we study, relate to disorders of digital public spaces: fragmentation, concentration, polarization, epistemic drift in internet communities.
The "Teachers as Researchers" programme: Citizen science to engage educators in the production of structured practice-based evidence at a large-scale
Every day, millions of educators try out new practices to improve education. To be effective, they need to build upon each other’s successes and failures. However, collaboratively producing evidence about their practices that can be trustworthy, compared across contexts, and aggregated at a large scale is challenging.
Since 2019, we are developing the “Teachers as Researchers” programme, a citizen science project to engage educators in the collaborative production of practice-based evidence as they daily experiment with new educational practices.
The "Teachers as Researchers" programme trains volunteer educators to create communities and to facilitate regular workshops in which community members follow a methodology designed to motivate collaboration and reflection about their practices while at the same time producing structured records of practice-based evidence. The work of communities is undertaken in a collaborative publication platform to promote wide collaboration across communities and to feed a shared and public database of practice-based evidence (https://plateforme.profschercheurs.org).
Affiliate faculty are researchers who are in close collaboration for CRI Research Collaboratory - they co-mentor a PhD student or a postdoc working conjointly at the CRI Research Collaboratory, collaborate with a CRI researcher on a specific, ongoing, funded project or are actively taking part in the intellectual life of the Collaboratory.